This mid-table clash sees seventh-placed Harlequins host 9th placed Gloucester at the 'Home Of Rugby.'
To Win (80 mins)
Harlequins 3/10 | Draw 21/1 | Gloucester 5/2
Meanwhile, Gloucester have rung the changes, making five in total to the starting XV that went down to La Rochelle on the 17th of this month. Scotsman Greg Laidlaw will resume the captaincy on his return, while Billy Twelvetrees, Ross Moriarty, Paddy McAllister and Mariano Galarza all come into the side respectively. Gloucester will be looking to overtake Quinn's on the Aviva Premiership table with a win here at Twickenham, and leapfrog both them and the Newcastle Falcons (who all sit on 23 points apiece).
Verdict: Harlequins 3/10
In what is sure to be a scrappy, low-scoring encounter, don't bet on another 10 tries being scored, as was the case when this fixture played out a year ago, ending in a 39-all draw. This while be a war of attrition, with the result depending on forward dominance and the boots of Captains Care and Laidlaw at half-back. Come the final whistle, however, it should be Care's Quinn's that come out trumps (expect Marler to have a stormer and boss the scrums). Playing at home, and with hardly any disruption to their starting line-up as opposed to their rivals, back Harlequins to make their Christmas season all the merrier.