The Proteas lead the three-match series after taking the opener in Paarl by 31 runs, and will want to wrap proceedings up with another win on Friday.
India will ant to bounce back and take the ODI series to a decider at Newlands in a mirror of the Test series.
South Africa vs India | Friday 21 January | Boland Park, Paarl | 10:30
To Win Match
South Africa 5/4 | Tie 25/1 | India 67/100
South Africa were lifted by an excellent middle order effort in their opening match after their form white-ball batsmen failed up front.
Quinnton de Kock and Janneman Malan are not in danger of losing their places, nor is Aiden Markram who has increasing value as an all-rounder.
With Kagiso Rabada rested for the ODIs, Marco Jansen is on course to get a decent run in the ODI XI.
Skipper Temba Bavuma and Rassie van der Dussen are in excellent form which should encourage the top order to play with more freedom.
Virat Kohli looks to be in decent touch after being freed from the burden of captaincy but his dismissal still sparked the India collapse the first time out.
Stand-in skipper KL Rahul has seen his use of bowlers questioned as Venkatesh Iyer did not turn his arm over on debut.
Shreyas Iyer might have to make way for Shubman Gill with places in the India middle-order clearly up for grabs.
Jasprit Bumrah provides a consistent threat and makes it hard for any team to attack from the outset and make the most of the death overs.
Verdict: South Africa 5/4
South Africa should keep their winning run going after comfortably seeing off the Indians in the first encounter in Paarl.